1. Define genotype and phenotype. Which one has the greatest influence on the intrinsic rate of aging? Which one has the greatest influence on the extrinsic rate of aging?
2. What are some of the factors that make identification of a biomarker for human aging challenging?
3. Consider the following experimental design for a study on how aging might affect hearing. Subjects in three age groups, 20-49, 40-69, and 70-90, will be exposed to different levels of sound, and their ability to hear the sounds will be compared. Is this an example of a cross-sectional or longitudinal design? Explain how the cohort effect and selective mortality will affect the results and conclusions.
4. Consider the graphs shown here, showing survival curves for two groups of mice. Which group of mice would you suspect to have the slower rate of aging? Why? What are the approximate mean and maximum life spans for each group?
Gerontology genotype and phenotype
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